The Dragons are looking to get back to winning ways after heavy defeats to Ulster and Connacht and a draw against Zebre.
If Lyn Jones' men can beat Edinburgh then they will climb to seventh in the table and stretch away from Welsh rivals Cardiff Blues.
The Scots still have hope of catching the Scarlets in the race for the final spot in next season's premier European tournament and edged the Murrayfield meeting between the sides 16-13 thanks to Harry Leonard's penalty with the final kick.
The Dragons have not lost to Edinburgh at Rodney Parade since 2006.
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